Labor dystocia and risk of histological chorioamnionitis and funisitis: a study from a single tertiary referral center

Abstract Background Intrauterine inflammation affects short- and long-term neonatal outcomes. Histological chorioamnionitis funisitis are acute inflammatory responses in the fetal membranes umbilical cord, respectively. Although labor dystocia includes a potential risk of intrauterine inflammation, histological has not been evaluated yet. This study aimed to examine association between funisitis. Methods In this retrospective cohort study, cases who underwent histopathological examinations placenta cord at Fukushima Medical University Hospital, Japan, 2015 2020, were included. From dataset, pathological findings patients with spontaneous preterm birth reviewed. Based on location leukocytes, (histological chorioamnionitis) (funisitis) was staged as 0–3. Multiple logistic regression analysis performed evaluate chorioamnionitis, stage ≥2, funisitis, ≥2. Result Of 317 women met criteria, 83 144 had birth, respectively, 90 included controls. Labor factor for (adjusted odds ratio, 6.3; 95% confidential interval, 1.9–20.5), ≥2 6.0; confidence 1.7–21.8), 15.4; 2.3–101.3), 18.5; 2.5–134.0). Spontaneous also 3.7; 1.7–7.8), 3.0; 1.2–7.9), 6.6; 1.4–30.6). However, adjusted ratio smaller births than dystocia. Conclusion is severe Further studies required effects